Development and Characterization of Chitosan-Pluronic Polymeric Nanoparticles for the Breast Cancer Treatment
نویسندگان
چکیده
The chitosan-pluronic nanoparticles have been prepared by an ionic gelation (IG) method. Particle size analysis, Scanning electron microscopy (SEM), Zeta potential measurements, Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) were used for nanoparticles characterization. The optimized tamoxifen loaded nanoparticles had a spherical shape with positive charge and mean diameter 150 to 300 nm. The FT-IR and DSC studies found that the drug was dispersed in amorphous form due to its potent interaction with nanoparticles matrix. The maximum encapsulation efficiency was obtained at 8mg/ml tamoxifen. The tamoxifen loaded chitosan-pluronic nanoparticles had good blood compatibility. All study results suggest that the nanoparticles could be used as an effective drug delivery carrier for the breast cancer treatment.
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